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Phenotype Image Detail
Image
Caption Phenotypes in Lmnatm1Lgf/Lmna+ mice. A; Radiograph of a 6 month old Lmnatm1Lgf/Lmna+ (LmnaHG/+) mouse and a littermate wild-type (Lmna+/+) mouse. C: Thorax of a six month old mutant mouse and a littermate wild-type mouse. Black arrowheads indicate fracture callus surrounding broken ribs. E: Surface renderings of microCT scans of the skulls of four month old mutant and and wild-type mice. Red arrows indicate a characteristic absence of the zigzag appearance of the cranial sutures and osteolytic lesions of the zygomatic arch. F: Surface renderings of microCT scans of the skulls of four month old mutant and wild-type mice. Red arrows in the mutant skull indicate micrognathia and the site of an osteolytic lesion of the zygomatic arch. H: Hematoxylin and eosin stained sections of the ascending aorta from a 7 month old mutant and littermate wild-type mouse. Original magnification, x20.
Copyright This image is from Yang SH, J Clin Invest 2006 Aug;116(8):2115-21 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:113119
Associated
Alleles
Symbol Name
Lmnatm1Lgf lamin A; targeted mutation 1, Loren G Fong
Associated
Genotypes
Allelic Composition Genetic Background
Lmnatm1Lgf/Lmna+ involves: 129P2/OlaHsd * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory