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| Caption | Electron micrographs reveal glomerular basement membrane abnormalities and foot process effacement in kidneys of mildly affected Cd151tm1Nki/Cd151tm1Nki (Cd151-/-) and Itga3tm1Son/Itga3tm1Son Tg(NPHS2-cre)295Lbh/0 (2.5P-Cre; Itga3fl/fl), but not Itga3tm1Son/Itga3+ Tg(NPHS2-cre)295Lbh/0 (2.5P-Cre; Itga3fl/+) mice. A: Glomeruli of 3 month old Cd151tm1Nki/Cd151tm1Nki mice show abnormal capillary loops characterized by glomerular basement membrane (GBM) thickening and loss of regular pattern of podocyte foot processes (FPs). B: Peripheral glomerular capillary with a luminal thrombocyte and loss of fenestrations (arrowhead). The GBM is irregularly thickened and shows protrusions toward the capsular space (*). Podocyte FPs are partially lost (arrows). C: Irregular GBM showing lamination, thickening and protrusions (*). The endothelium is swollen and fenestrations are partially lost (arrowheads), as are podocyte FPs (arrows). Glomeruli of 6 week old Itga3tm1Son/Itga3+ Tg(NPHS2-cre)295Lbh/0 (2.5P-Cre; Itga3+/fl) mice do not show abnormalities (D), whereas all glomeruli of Itga3tm1Son/Itga3tm1Son Tg(NPHS2-cre)295Lbh/0 (2.5P-Cre; Itga3fl/fl) mice exhibit severe structural changes (E and F). E: Abnormally thickened GBM with protusions throughout the glomerulus. F: Podocyte FPs are completely lost (arrows) and GBM protusions (*) are present along the entire length of the capillary loops. Solid lines point to normal structures (GBM and FPs), whereas dotted lines indicate abnormal thickening of the GBM and effacement of FPs. Bc, Bowman's capsule; Cs, capsular space; E, erythrocyte; Ec, endothelial cell; Fp, foot process; Lb, lamina basalis (GBM); Pdc, podocyte; T, thrombocyte; V, vascular lumen. Bars: A, D and E, 10 um; B, C and F, 2 um. | ||||||||
| Copyright | This image is from Sachs N, J Cell Biol 2006 Oct 9;175(1):33-9, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:114988 | ||||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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