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| Caption | Electron micrographs of brain capillaries in wild type (A and C) and Pdgfbtm1Cbet/Pdgfbtm1Cbet (PDGFB-/-, B and D-H) embryos at E18.5. Capillaries in wild type embryonic brains exhibited a smooth luminal and abluminal endothelial surface and a homogeneous thickness of the endothelium (A and C), whereas those in mutant embryos were of highly variable thickness (B and D). Luminal microfolds greatly enlarged the endothelial surface (D), and perivascular glial swelling was prominent (star in D). Caveolae were abundant in the endothelium of mutant embryos (E-H), both near the luminal (arrows) and the abluminal surface (boxed area, enlarged in G and H). In G, a series of caveolae appeared almost to connect the luminal and the abluminal compartment. Bars: A and B, 10um; C-F, 1um; G and H, 100nm. | ||||
| Copyright | This image is from Hellstrom M, J Cell Biol 2001 Apr 30;153(3):543-53, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:78912 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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