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Phenotype Image Detail
Image
Caption A: Open arrows denote connecting cilia of cone photoreceptors for reference. Then wild type (WT) cone outer segment measures 1.3 um at its widest point and tapers distally; B, cone inner segments were sometimes observed to contain electron-dense granules (stars). C: Disorganized Gucy2etm1Gar/Gucy2etm1Gar (GC1-/-) cone outer segment reveals apparent partitioning of membrane components; lamellar structures emanate from one side of the distal connecting cilium and vesicles from the tip. D: Adjacent to the retinal pigmented epithelium (RPE), extracellular particle (2-3 um in diameter) containing vesicles and tubules surrounded by membrane lamellae appears as an end product of membrane component sorting. E: Another example of membrane partitioning is shown in which membrane layers are found to one side of the distal connecting cilium and vesicles/tubules extend from its tip. Cones were examined in a location inferior to the optic nerve for each genotype.
Copyright This image is from Baehr W, J Biol Chem 2007 Mar 23;282(12):8837-47 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:120903
Associated
Alleles
Symbol Name
Gucy2etm1Gar guanylate cyclase 2e; targeted mutation 1, David L Garbers
Associated
Genotypes
Allelic Composition Genetic Background
Gucy2etm1Gar/Gucy2etm1Gar involves: 129S6/SvEvTac

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory