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Phenotype Image Detail
Image
Caption Whole hearts and cardiac muscle sections. Hearts from 10 week old Destm1Cap/Destm1Cap (-/-, A) and wild type (WT, E) mice demonstrate extensive areas of degeneration and calcification throughout the myocardium of mutant mice. Sections from mutant mice (B and C) and corresponding areas in wild type (F and G) were stained with Masson's trichrome to reveal areas of interstitial fibrosis and degeneration. High magnification of cardiac myofibers taken from nonfibrotic regions of mutant myocardium (D) and wild type (H) myocardium stained with hematoxylin and eosin. Several of the fibers from the mutant myocardium appear to be disrupted and disintegrating. Bars: D and H, 5um; C and G, 10um.
Copyright This image is from Milner DJ, J Cell Biol 1996 Sep;134(5):1255-70, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:35123
Associated
Alleles
Symbol Name
Destm1Cap desmin; targeted mutation 1, Yassemi Capetanaki
Associated
Genotypes
Allelic Composition Genetic Background
Destm1Cap/Destm1Cap involves: 129S7/SvEvBrd * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory