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Caption Skeletal staining of newborn vertebral columns derived from wild-type (+/+) and Col2a1tm1Prc/Col2a1tm1Prc (-/-) mice. Verterbral columns from wild type (A and C) and mutant mice (B and D) were stained with alizarin red and alcian blue. In the wild type, a ventral view of the thoracic regions (A) showed adjacent vertebral bodies (vb) were separated by well-formed intervertebral discs (ivd) that contained a gelatinous nucleus pulposus (np) in the center and cartilaginous inner annulus (ia) at the periphery. In contrast, the intervertebral discs of the mutant mice (B) lacked the nucleus pulposus. The neighboring vertebral bodies (vb) were connected via blue stained cartilaginous bridges (arrows). C and D: Lateral views of the fifth thoracic vertebra from wild type (C) and mutant (D) mice. Vertebral arches of mutant vertebrae failed to fuse. Note that the mutant vertebral body is composed of a blue, cartilaginous tissue that is surrounded by a thin, red, bony sheath.
Copyright This image is from Aszodi A, J Cell Biol 1998 Nov 30;143(5):1399-412, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:51376
Symbol Name
Col2a1tm1Prc collagen, type II, alpha 1; targeted mutation 1, Darwin J Prockop
Allelic Composition Genetic Background
Col2a1tm1Prc/Col2a1tm1Prc involves: 129/Sv * C57BL/6

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