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Phenotype Image Detail
Caption Analysis of Tsc2tm1Djk/Tsc2tm1Djk embryos. A: Immunoblot analysis demonstrating lack of tuberin expression in Tsc2tm1Djk/Tsc2tm1Djk (-/-) embryos using mAb 5E8. B: Gross anatomy of homozygous mutant embryos. C-F: Histology of mutant (C and E) and wild type (D and F) embryos. C and D: Full embryo section, identical magnification. Insets indicate area of view enlarged in E and F. E and F: Liver and adjacent organs, identical magnification. H, heart; L, liver. The mutant embryo is overall smaller, and the liver is markedly hypoplastic with dilated sinusoids (arrows) in contrast to the normal liver. Scale bars: B-D, 2mm; E and F, 200um.
Copyright This image is from Onda H, J Clin Invest 1999 Sep;104(6):687-95 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:57631
Symbol Name
Tsc2tm1Djk tuberous sclerosis 2; targeted mutation 1, David J Kwiatkowski
Allelic Composition Genetic Background
Tsc2tm1Djk/Tsc2tm1Djk either: (involves: 129S4/SvJae * BALB/cJ) or (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6J)

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