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Phenotype Image Detail
Image
Caption Top panel shows eyes of live mice, CrygsOpj/Crygs+ ( (Opj/+, left) and CrygsOpj/CrygsOpj mice (Opj/Opj, center and right). For the first 2-3 months of life there is little difference in appearance between heterozygous and homozygous mouse eyes, but in the homozygote, opacity increases in severity with age. The lower panel shows isolated lenses for wild type (+/+), heterozygous and homozygous mice at 5 weeks and homozygous at 8 months. At early stages the mutation causes secondary fiber discontinuity, most notably in the homozygous mouse.
Copyright This image is from Sinha D, J Biol Chem 2001 Mar 23;276(12):9308-15 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:68109
Associated
Alleles
Symbol Name
CrygsOpj crystallin, gamma S; opacity due to poor secondary fiber cell junctions
Associated
Genotypes
Allelic Composition Genetic Background
CrygsOpj/Crygs+ involves: 102 * C3H/He * T STOCK
CrygsOpj/CrygsOpj involves: 102 * C3H/He * T STOCK

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory