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Phenotype Image Detail
Caption The skeletons from newborn wild type, Pthtm1Dgo/Pthtm1Dgo (PTH-/-), Pthlhtm1Hmk/Pthlhtm1Hmk (PTHrP-/-) and Pthtm1Dgo/Pthtm1Dgo Pthlhtm1Hmk/Pthlhtm1Hmk (PTH-/- , PTHrP-/-) mice were stained with Alcian blue (for cartilage) and alizarin red (for calcified tissue). A-D: Whole mount of skeletons. E-H: Sections of tibiae from wild type, Pthtm1Dgo/Pthtm1Dgo, Pthlhtm1Hmk/Pthlhtm1Hmk, and Pthtm1Dgo/Pthtm1Dgo Pthlhtm1Hmk/Pthlhtm1Hmk mice stained with hematoxylin and eosin and photographed at a magnification of 25. P, proliferating zone; H, hypertrophic zone; B, bone tissue. I and J: The length of whole tibiae, of the proliferating zones (PZs), and of the hypertrophic zones (HZs) of the growth plates were measured from three each of the wild type, Pthtm1Dgo/Pthtm1Dgo, Pthlhtm1Hmk/Pthlhtm1Hmk, and Pthtm1Dgo/Pthtm1Dgo Pthlhtm1Hmk/Pthlhtm1Hmk mice and are presented as mean +/-SEM, respectively. K: The length of tibial bone tissue is presented as the mean +/- SEM of three determinations. *P < 0.05, mutant mice relative to wild type mice. #P < 0.05 in double mutant mice relative to Pthtm1Dgo/Pthtm1Dgo or Pthlhtm1Hmk/Pthlhtm1Hmk mice.
Copyright This image is from Miao D, J Clin Invest 2002 May;109(9):1173-82 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:76407
Symbol Name
Pthtm1Dgo parathyroid hormone; targeted mutation 1, David Goltzman
Pthlhtm1Hmk parathyroid hormone-like peptide; targeted mutation 1, Henry M Kronenberg
Allelic Composition Genetic Background
Pthtm1Dgo/Pthtm1Dgo involves: 129S2/SvPas * C57BL/6J
involves: 129S2/SvPas * C57BL/6J
Pthlhtm1Hmk/Pthlhtm1Hmk involves: 129S2/SvPas * C57BL/6J

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