Phenotype Image Detail

Image

Caption

Bmpr1a and Bmpr1b are functionally redundant during chondrogenesis. A: Gross appearance of E14.5 wild type (WT) and Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Bmpr1b^tm1Kml/Bmpr1b^tm1Kml Tg(Col2a1-cre)1Bhr/? embryos (Bmpr1a^CKO;Bmpr1b^-/-). Mutant embryos have widened and flattened thoracic cavities, shortened limbs, and exposed neural tissue but have correctly patterned digits (arrow). B: Skeletal preparations of postnatal day 0 embryos. Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Tg(Col2a1-cre)1Bhr/? (Bmpr1a^CKO) mice have a mild generalized chondrodysplasia, which leads to a smaller thoracic cavity and shortening of long bones. In contrast, skeletal elements that form through endochondral ossification are completely absent or rudimentary in Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Bmpr1b^tm1Kml/Bmpr1b^tm1Kml Tg(Col2a1-cre)1Bhr/? (Bmpr1a^CKO; Bmpr1b^-/-) mice.

Associated
Alleles

Symbol	Name
Bmpr1a^tm2.1Bhr	bone morphogenetic protein receptor, type 1A; targeted mutation 2.1, Richard R Behringer
Bmpr1b^tm1Kml	bone morphogenetic protein receptor, type 1B; targeted mutation 1, Karen M Lyons
Tg(Col2a1-cre)1Bhr	transgene insertion 1, Richard R Behringer

Associated
Genotypes

Allelic Composition	Genetic Background
Bmpr1b^tm1Kml/Bmpr1b^tm1Kml	involves: 129S/SvEv
Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Bmpr1b^tm1Kml/Bmpr1b^tm1Kml Tg(Col2a1-cre)1Bhr/?	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL
Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Tg(Col2a1-cre)1Bhr/?	involves: 129S7/SvEvBrd * C57BL/6 * SJL

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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