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Phenotype Image Detail
Caption A: Macroscopic views of tympanic membrane from wild type (+/+) and Eya4tm1Jse/Eya4tm1Jse (-/-) mice. Mutant mouse ears had air bubbles (asterisk), indicative of middle ear effusion, and dilated capillaries (black arrow) as well as tympanic membrane retraction. Scale bars: 1mm. B and C: PAS-stained paraffin sections of mice, age 3 weeks. (B) The mesotympanum of middle ear cavity shows inflammatory cells (red arrow) in mutant mice, and the mucoperiosteum (black arrowheads) is thickened. A, stapedial artery; I, incus; M, malleus; OW, boney niche of the oval window; T, tympanic membrane. Scale bars: 200um. (C) The hypotympanum regions of mutant mice show effusion (asterisk), inflammatory cells (red arrow), hyperplastic ciliated epithelial cells (black arrows), and expanded lamina propria connective tissue in the mucoperiosteum (arrowhead; corresponding regions denoted by gray arrow/arrowhead in wild type). MEC, middle ear cavity.
Copyright This image is from Depreux FF, J Clin Invest 2008 Feb;118(2):651-8 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:131873
Symbol Name
Eya4tm1Jse EYA transcriptional coactivator and phosphatase 4; targeted mutation 1, Jonathan G Seidman
Allelic Composition Genetic Background
Eya4tm1Jse/Eya4tm1Jse involves: 129S6/SvEvTac * CBA/J

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