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Phenotype Image Detail
Caption Electron micrographs of left-ventricular myocytes from wild type (A and B) and Casq2tm1Klmn/Casq2tm1Klmn (C-G) mouse hearts. Flat junctional sarcoplasmic reticulum (jSR) cisternae are closely apposed to T tubules (T). In wild type myocytes, cisternae are quite uniform in width and filled by calsequestrin, which is periodically arranged in small clumps ( A and B, between arrows). "Feet" (RyRs) are present in the juntional gap between the two membranes. In the mutant mouse myocytes, the jSR has variable width and is apparently empty (C-F, between arrows). (G) Longitudinal sarcoplasmic reticulum (SR) of mutant myocyte in a section that was cut tangentially to the myofibrils. The SR forms a network with large fenestrations covering the A bands and continuing across Z lines (Z). In proximity to the T tubules, the SR runs in a transverse orientation, accompanying the T tubule profiles. The SR network is quite abundant in muatnt myocytes.
Copyright This image is from Knollmann BC, J Clin Invest 2006 Sep;116(9):2510-20 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:114621
Symbol Name
Casq2tm1Klmn calsequestrin 2; targeted mutation 1, Bjorn C Knollmann
Allelic Composition Genetic Background
Casq2tm1Klmn/Casq2tm1Klmn involves: 129S1/Sv * 129X1/SvJ * C57BL/6

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