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Phenotype Image Detail
Caption A: A characteristic buffalo hump in a 5 day old Ppargtm2(tTA)Yba/Pparg+ pup (Idi/+) (arrow). B and C: Brown adipose tissue (BAT) of wild type (+/+) and mutant mice. Mutant BAT exhibits markedly enlarged lipid droplets with unilocular vs. multilocular deposition (C vs. B). D and E: Wild type and mutant mouse skin. Subdermal fat is eliminated in mutant mice. F and G: Epididymal fat pads (EEP) of wild type and mutant mice. White adipose mass is substantially decimated in mutant mice. H-K: Histology of wild type and mutant white adipose tissue (WAT). I: A domain of marked adipocyte hypertrophy in mutant mouse tissue. J: Another domain in the same EFP with minuscule cells, fragmented lipid droplets, and marked leukocyte infiltration. K: A higher power micrograph of J Inset, with clear leukocytes and fragmented lipid droplets. L-O: Complete phenotypic reversal in mutant mice treated with dox from gestation onwards. Shown are BAT (L), skin (M), EEP (N), and WAT (O); compare with untreated mutants in C, E, G, I-J, respectively. All tissue specimens, except in A, are from 10 week old male mice. Scale bars: B, C, H-J, L and O, 50um; D, E and M, 250um; K, 10um.
Copyright This image is from Kim S, Proc Natl Acad Sci U S A 2007 Oct 16;104(42):16627-32. Copyright 2007 National Academy of Sciences, U.S.A. J:125992
Symbol Name
Ppargtm2(tTA)Yba peroxisome proliferator activated receptor gamma; targeted mutation 2, Yaacob Barak
Allelic Composition Genetic Background
Ppargtm2(tTA)Yba/Pparg+ involves: 129S1/SvImJ * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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