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Caption Hearts from 5 month old Dmdmdx/? Myod1tm1Jae/Myod1tm1Jae mice (mdx:MyoD-/-, right) were compared with age-matched wild type littermates (left). A: Intact hearts of mutant mice appeared significantly larger than hearts from wild type mice. B: Hematoxylin and eosin stained sections of hearts (cut transversely at midventricle) revealed an increased ventricular diameter in mutant mice compared with wild type mice. Although hearts were fixed ex vivo without diastole arrest, the apparent increase in ventricular diameter without concurrent changes in ventricular thickness suggests dilatation. C: Cardiomyocyte hypertrophy and disarray in mutant mouse hearts are observed, which are not present in wild type mice. Magnification: A and B, 2mm; C, x40.
Copyright This image is from Megeney LA, Proc Natl Acad Sci U S A 1999 Jan 5;96(1):220-5. Copyright 1999 National Academy of Sciences, U.S.A. J:52248
Associated
Alleles
Symbol Name
Dmdmdx dystrophin, muscular dystrophy; X linked muscular dystrophy
Myod1tm1Jae myogenic differentiation 1; targeted mutation 1, Rudolf Jaenisch
Associated
Genotypes
Allelic Composition Genetic Background
Dmdmdx/?
Myod1tm1Jae/Myod1tm1Jae
involves: 129S4/SvJae * C57BL/10ScSn

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory