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Phenotype Image Detail
Caption Mice were aged matched and analyzed by slit-lamp examination; representative GpnmbR150X/GpnmbR150X Tyrp1b/Tyrp1b eyes are shown. A: The normally brown pigmented coat of a mouse on the left compared with a GpnmbR150X/GpnmbR150X Tyrc-2J/Tyrc-2J Tyrp1b/Tyrp1b mouse on the right. B,D,F: Different views emphasize the clinical morphology of the albino iris. Eyes of Tyrc-2J/Tyrc-2J mice appear pink as they lack melanin, but otherwise the iris and its vasculature have normal morphology. C, E,G: Homozygosity for Tyrc-2J completely prevents iris disease in triple homozygous mutant mice. The iris morphology of the triple mutant is indistinguishable from that of Tyrc-2J/Tyrc-2J only (compare 3B to 3C), lacks peripupillary abnormalities (compare 3D to 3 E), and has a healthy uninterrupted vasculature (3F to 3G).
Copyright This image is from Anderson MG, BMC Biol 2006;4():20, an open-access article, licensee BioMed Central Ltd. J:128215
Symbol Name
GpnmbR150X glycoprotein (transmembrane) nmb; iris pigment dispersion
Tyrc-2J tyrosinase; albino 2 Jackson
Tyrp1b tyrosinase-related protein 1; brown
Allelic Composition Genetic Background
B6.Cg-Tyrp1b GpnmbR150X Tyrc-2J

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