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Phenotype Image Detail
Image
Caption Loss of tyrosine hydroxylase immunoreactivity (TH-IR) in the locus coeruleus (LC), but not substantia nigra pars compacta (SNpc) or striatum of Park2tm1Tmd/Park2tm1Tmd mice. Immunohistochemical staining for TH (C-F: with Nissl counterstain) was performed on coronal brain sections from wild type (A,C & E) and mutant mice (B,D & F) mice. (A & B) Striatum. (C & D) Midbrain with SN and ventral tegmental area. (E & F) LC. (Insets) A lower magnification of the same sections to verify that both pictures represent equivalent planes. Scale bar: 200um
Copyright This image is from Von Coelln R, Proc Natl Acad Sci U S A 2004 Jul 20;101(29):10744-9. Copyright 2004 National Academy of Sciences, U.S.A. J:91487
Associated
Alleles
Symbol Name
Park2tm1Tmd Parkinson disease (autosomal recessive, juvenile) 2, parkin; targeted mutation 1, Ted M Dawson
Associated
Genotypes
Allelic Composition Genetic Background
Park2tm1Tmd/Park2tm1Tmd involves: C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory