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Phenotype Image Detail
Image
Caption Hearts were fixed in formalin and paraffin sections prepared and stained with either hematoxylin and eosin (A & B) or trichrome (C-F) to highlight the interstitial fibrosis. Representative low-power views from a control heart (A) and individual binary transgenic hearts (B-D). Note the chamber dilatation (B & C) and marked variability in the extent of fibrosis (C & D) in binary hearts. Higher power views demonstrate the presence of scant residual myocytes in the most severe lesions (E & F).
Copyright This image is from Lee P, Proc Natl Acad Sci U S A 1998 Sep 15;95(19):11371-6. Copyright 1998 National Academy of Sciences, U.S.A. J:128617
Associated
Alleles
Symbol Name
Tg(Myh6-tTA)6Smbf transgene insertion 6, Section of Myocardial Biology - Fishman Lab
Tg(tetO-DTA)1Gfi transgene insertion 1, Glenn I Fishman
Associated
Genotypes
Allelic Composition Genetic Background
Tg(Myh6-tTA)6Smbf/0
Tg(tetO-DTA)1Gfi/0
involves: C57BL/6 * CBA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory