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Phenotype Image Detail
Image
Caption D: Hematoxylin and eosin, and Oil-red-O stainings reveal the swelling of hepatocytes with formation of large lipid-containing vesicles in KitMhdasco5/KitMhdasco5 versus wild type littermates at 7.5 and 10.5 days post partum (dpp). G: At 0.5 dpp, the Oil-red-O staining of liver sections from homozygous and wild type mice which had not yet suckled, are identical showing no accumulation of lipids. However, after breast feeding, hepatocytes from wild type newborns appear to stock lipids inside microvesicles at 1.5 dpp, a phenomenon that is not observed at later stages. On the contrary, in homozygous mice which have suckled milk from their mother, lipids accumulation is still found in hepatic cells after 1.5 dpp.
Copyright This image is from Magnol L, BMC Dev Biol 2007;7():81, an open-access article, licensee BioMed Central Ltd. J:125831
Associated
Alleles
Symbol Name
KitMhdasco5 KIT proto-oncogene receptor tyrosine kinase; Martin Hrabe de Angelis spotted coat 5
Associated
Genotypes
Allelic Composition Genetic Background
KitMhdasco5/KitMhdasco5 C3HeB/FeJ-KitMhdasco5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory