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Phenotype Image Detail
Image
Caption A: Size of Serpini2pq/Serpini2pq mice (center) in relation to wild type (left) and Serpini2pq/Serpini2+ littermates (right) at 8 weeks of age. C-H: Pancreas hematoxylin and eosin histological analyses were performed on 8 week old (C, D, E), 3 week old (F), and 1 week old (G & H) mice. Wild type acinar cells (C) and heterozygous acinar cells (D) at 8 weeks of age were morophologically normal. This is in contrast to homozygous mice at 8 weeks of age (E) and 3 weeks of age (F), where there is a severe loss of exocrine pancreatic acinar cells while duct cells and islet cells (arrows) are normal. Acinar cells are present in pancreas samples from 1 week old homozygous mice (H), but the cells are smaller and show reduced cytosolic volume when compared to wild type littermates (G). Scale bar: 25um
Copyright This image is from Loftus SK, PLoS Genet 2005 Sep;1(3):e38, an open-access article distributed under the terms of the Creative Commons Attribution License. J:115744
Associated
Alleles
Symbol Name
Serpini2pq serine (or cysteine) peptidase inhibitor, clade I, member 2; pequeno
Associated
Genotypes
Allelic Composition Genetic Background
Serpini2pq/Serpini2pq involves: C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory