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Phenotype Image Detail
Caption A: E17.5 wild type diaphragm viewed from the top showing the liver underneath. B: E17.5 Slit3tm1Dor/Slit3tm1Dor diaphragm showing a CDH (congenital diaphragmatic hernia) sac containing liver tissue (arrow). C: Sagittal section of a CDH in a P14 homozygous mutant mouse. D-F: Higher magnification views of the boxed areas indicated in C. G: Detection of beta-gal in the lung of an E18.5 homozygous embryo by 5-bromo-4-chloro-3-indolyl beta D-galactoside staining. H: Lung section of a P14 homozygous mouse with CDH. I & J: Lung sections of a 5 week old wild type (I) and homozygous mouse showing pulmonary congestion in the homozygous mouse tissue.
Copyright This image is from Yuan W, Proc Natl Acad Sci U S A 2003 Apr 29;100(9):5217-22. Copyright 2003 National Academy of Sciences, U.S.A. J:83292
Symbol Name
Slit3tm1Dor slit guidance ligand 3; targeted mutation 1, David M Ornitz
Allelic Composition Genetic Background
Slit3tm1Dor/Slit3tm1Dor involves: 129S1/Sv * C57BL/6J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory