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Phenotype Image Detail
Caption At 21 days of age, normal hepatic morphology consists of uniform hepatocytes with bland nuclei that contain small nucleoli (A). In Cbstm1Unc/Cbs+ mice (B), the hepatocytes have anisonucleosis and fairly prominent nucleoli and appear to be slightly larger. Cbstm1Unc/Cbstm1Unc mice (C) have enlarged pleomorphic hepatocytes with large, prominent nucleoli. The hepatocytes are frequently binucleated or multinucleated, and their cytoplasm often contains multivesicular cytoplasmic lipid droplets. Magnification: x130
Copyright This image is from Watanabe M, Proc Natl Acad Sci U S A 1995 Feb 28;92(5):1585-9. Copyright 1995 National Academy of Sciences, U.S.A. J:23321
Symbol Name
Cbstm1Unc cystathionine beta-synthase; targeted mutation 1, University of North Carolina
Allelic Composition Genetic Background
Cbstm1Unc/Cbstm1Unc involves: 129P2/OlaHsd * C57BL/6J
Cbstm1Unc/Cbs+ involves: 129P2/OlaHsd * C57BL/6J

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