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| Caption | A & B: The two upper panels display the yolk sac of Psen1tm1Bdes/Psen1+ Psen2tm1Bdes/Psen2tm1Bdes (A) and Psen1tm1Bdes/Psen1tm1Bdes Psen2tm1Bdes/Psen2tm1Bdes (B) littermates (identical magnification). The arrowhead points to the vascular plexus. Although initial vascular plexus and primitive red blood cells form in the double mutant, organization into a discrete network of vitelline vessels is lacking, yolk sacs do not expand properly and often have a blistered appearance. C & D: Psen2tm1Bdes/Psen2tm1Bdes (C) and Psen1tm1Bdes/Psen1+ Psen2tm1Bdes/Psen2tm1Bdes (D) embryos appear normal. E: The neural tube of E9.5 double homozygous embryos often has a kinked appearance. F: Psen1tm1Bdes/Psen1tm1Bdes embryos are only marginally retarded at E9.5. Magnification is identical for C-F | ||||||
| Copyright | This image is from Herreman A, Proc Natl Acad Sci U S A 1999 Oct 12;96(21):11872-7. Copyright 1999 National Academy of Sciences, U.S.A. J:58118 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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