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Phenotype Image Detail
Image
Caption Hematoxylin and eosin stained sagittal brain sections from a 6 month old wild type and age matched Ppt1tm1Hof/Ppt1tm1Hof mouse. A: Homozygous mutant mouse hippocampus showing ballooning degeneration and loss of neurons. Large arrows denote ballooning of neurons; small arrows show neuronal apoptotic bodies. B: Homozygous mutant mouse Purkinje neurons in the cerebellum show neuronal loss, resulting in a discontinuous Purkinje layer. C: Wild-type hippocampal region. D: Wild-type Purkinje neurons of the cerebellum. Scalebar: 40um
Copyright This image is from Gupta P, Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13566-71. Copyright 2001 National Academy of Sciences, U.S.A. J:72931
Associated
Alleles
Symbol Name
Ppt1tm1Hof palmitoyl-protein thioesterase 1; targeted mutation 1, Sandra L Hoffmann
Associated
Genotypes
Allelic Composition Genetic Background
Ppt1tm1Hof/Ppt1tm1Hof involves: 129S6/SvEvTac * C57BL/6J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory