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Phenotype Image Detail
Image
Caption Plastic sections (1um) of eyes from wild type and Pax6Sey/Pax6+ mice at E13.5 (A & B) and E16.5 (C-F). A: Extensive vacuolation of the heterozygous mutant eye lens is seen, with persistence of a lens-corneal plug (arrowhead). B: A wild type littermate. C-F: Lens-corneal plug, an adhesion between the corneal epithelium and the lens epithelium (arrowhead) persists at E16.5. D: A wild-type E16.5 eye. E: Multiple adhesions between the lens and corneal endothelium in the E16.5 heterozygous mouse eye with reduction of the anterior chamber. G: BrdUrd staining (brown) in E12.5 lens shows no defects in the pattern of proliferation of the heterozygous mutant mouse eyes. H: Flourescence TUNEL in the E12.5 heterozygous mouse lens shows apoptotic cells only in the lens-corneal bridge. Apoptotic cells were not found in the lens epithelium of E12.5 wild type littermates eyes. Abbreviations: cornea (c); neural retina (ne) corneal epithelium (ce); lens epithelium (le) Scalebar: 50um
Copyright This image is from Collinson JM, Proc Natl Acad Sci U S A 2001 Aug 14;98(17):9688-93. Copyright 2001 National Academy of Sciences, U.S.A. J:71087
Associated
Alleles
Symbol Name
Pax6Sey paired box 6; small eye
Associated
Genotypes
Allelic Composition Genetic Background
Pax6Sey/Pax6+ Not Specified

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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory