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| Caption | Staining of calcified tissue in neonatal mice with alizarin red S. From left to right are wild-type mouse (A), Tg(Col2a1-PTHLH)2Ecw/0 mouse (B) Pthlhtm1Hmk/Pthlhtm1Hmk mouse (C) and Pthlhtm1Hmk/Pthlhtm1Hmk Tg(Col2a1-PTHLH)2Ecw/0 mouse (D). The Pthlhtm1Hmk/Pthlhtm1Hmk mice display inappropriate ossification of the costal cartilage and along the length of the sternum. These abnormalities appear to be largely corrected in the Pthlhtm1Hmk/Pthlhtm1Hmk Tg(Col2a1-PTHLH)2Ecw/0 mice (D), in which ossification is confined to the sternebrae and does not extend to the costal cartilage. A magnified view of the cranium (H) shows substantial correction of the accelerated mineralization of the endochondral bones of the cranial base seen in the knockout (G); s, supraoccipital; b, basioccipital; e, exoccipital; t, tympanic ring. The tips of the emerging mandibular incisors can be discerned in both the normal (E) and transgenic (F) animals, but not in the knockout (G) or rescued-knockout (H) mice. | ||||||||
| Copyright | This image is from Philbrick WM, Proc Natl Acad Sci U S A 1998 Sep 29;95(20):11846-51. Copyright 1998 National Academy of Sciences, U.S.A. J:50144 | ||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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