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Phenotype Image Detail
Image
Caption A: Images of 5 month old homozygous Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh (TTD/TTD) mouse (left), a compound heterozygous Ercc2tm2(ERCC2)Jhjh/Ercc2tm2Jmch (TTD/tXPCS) mouse (center) and a wild-type (wt/wt) mouse (right). Inserts: Images of first-round hair loss. B: Histological analysis of the skin of a homozygous (left), compound heterozygous (center) and wild-type mouse (right). Trichothidystrophy(TTD)-associated acanthosis (thicker epidermis, indicated by solid vertical line), pronounced granular layer (indicated by arrows), and sebacious gland hyperplasia (indicated by dotted verticle line) were absent in the epidermis of the compound heterozygote and wild-type mice. Magnification: x400
Copyright This image is from Andressoo JO, PLoS Biol 2006 Oct;4(10):e322, an open-access article distributed under the terms of the Creative Commons Attribution License. J:116054
Associated
Alleles
Symbol Name
Ercc2tm2(ERCC2)Jhjh excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 2, Jan H J Hoeijmakers
Ercc2tm2Jmch excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 2, James R Mitchell
Associated
Genotypes
Allelic Composition Genetic Background
Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh involves: 129P2/OlaHsd * C57BL/6
Ercc2tm2(ERCC2)Jhjh/Ercc2tm2Jmch involves: 129P2/OlaHsd * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory