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Phenotype Image Detail
Image
Caption A: Wild-type tubules show continuous peripheral layer of meiocytes with SCP3 staining. B: Nearly 50% of fourth generation Terctm1Rdp/Terctm1Rdp (G4) tubules exhibit complete absence of or very few meiocytes with SCP3 staining. Green, SCP3 elements; blue, nuclear chromosomes stained with DAPI. C: Rare apoptosis of wild-type seminferous tubules. D: Extensive apoptosis, indicated by green or yellow in the Terctm1Rdp/Terctm1Rdp seminferous tubules. Red, nuclear staining with propidium iodide.
Copyright This image is from Liu L, Proc Natl Acad Sci U S A 2004 Apr 27;101(17):6496-501. Copyright 2004 National Academy of Sciences, U.S.A. J:89751
Associated
Alleles
Symbol Name
Terctm1Rdp telomerase RNA component; targeted mutation 1, Ronald DePinho
Associated
Genotypes
Allelic Composition Genetic Background
Terctm1Rdp/Terctm1Rdp involves: 129/Sv * C57BL/6J * SJL

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory