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Phenotype Image Detail
Caption A: Macroscopic appearance of Tsc1tm1Hin/Tsc1+ (left) and Tsc1tm1Hin/Tsc1tm1Hin (right) embryos at E12.0. Arrows point to the unclosed neural tube exhibiting exencephaly. B: Histology of head region of heterozygous (left) and homozygous (right) mutant embryos at E12.0 shown by HE staining. Field of homozygous mutant is enlarged with twice the magnitude of that of the heterozygous mutant. Arrows point to the unclosed region of the neural fold exposed to the outside. C: Immunostaining of neural tube with anti-class III beta-tubulin antibody (TuJ1). Sections of the head region from the heterozygous and homozygous mutant embryos at E12.0 were stained with TuJ1. After immunostaining, a counterstain with HE was performed. Positive signals were seen as brown staining. D: Histological analysis of heart from wildtype (left) and homozygous mutant (right) embryos at E12.0 HE stained. Lower: Enlarged view of the region enclosed with a rectangle in the upper panel. Abbreviations: ventricular zone (VZ); marginal zone (MZ); left atrium (LA); left ventricle (LV); right atrium (RA); right ventricle (RV) Scalebars: B & C: 200um; D: 100um
Copyright This image is from Kobayashi T, Proc Natl Acad Sci U S A 2001 Jul 17;98(15):8762-7. Copyright 2001 National Academy of Sciences, U.S.A. J:70463
Symbol Name
Tsc1tm1Hin tuberous sclerosis 1; targeted mutation 1, Okio Hino
Allelic Composition Genetic Background
Tsc1tm1Hin/Tsc1tm1Hin involves: 129S4/SvJae * C57BL/6J

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