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| Caption | A: Macroscopic appearance of Tsc1tm1Hin/Tsc1+ (left) and Tsc1tm1Hin/Tsc1tm1Hin (right) embryos at E12.0. Arrows point to the unclosed neural tube exhibiting exencephaly. B: Histology of head region of heterozygous (left) and homozygous (right) mutant embryos at E12.0 shown by HE staining. Field of homozygous mutant is enlarged with twice the magnitude of that of the heterozygous mutant. Arrows point to the unclosed region of the neural fold exposed to the outside. C: Immunostaining of neural tube with anti-class III beta-tubulin antibody (TuJ1). Sections of the head region from the heterozygous and homozygous mutant embryos at E12.0 were stained with TuJ1. After immunostaining, a counterstain with HE was performed. Positive signals were seen as brown staining. D: Histological analysis of heart from wildtype (left) and homozygous mutant (right) embryos at E12.0 HE stained. Lower: Enlarged view of the region enclosed with a rectangle in the upper panel. Abbreviations: ventricular zone (VZ); marginal zone (MZ); left atrium (LA); left ventricle (LV); right atrium (RA); right ventricle (RV) Scalebars: B & C: 200um; D: 100um | ||||
| Copyright | This image is from Kobayashi T, Proc Natl Acad Sci U S A 2001 Jul 17;98(15):8762-7. Copyright 2001 National Academy of Sciences, U.S.A. J:70463 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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