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Phenotype Image Detail
Caption A: A section of normal lung from a 12 month old wild type mouse with a normal terminal bronchiole and alveoli lined predominantly with flattened type I pneumocytes (hematoxylin/eosin stain). B: An early lesion from a 12 month old Abca1tm1Jdm/Abca1tm1Jdm mouse including numerous foamy cells (arrows) and cholesterol clefts (arrowheads). Alveolar septae are focally expanded by mild type II pheumocyte hypertrophy, macrophages, and aggregates of lymphocytes and plasma cells. C: An Oil red O-stained section of lung from a 7 month old homozygous mouse demonstrates lipid accumulation with alveolar cells (arrow). D" By electron microscopy, these cells are identified primarily as type II pneumocytes (arrows) and intraalveolar macrophages (arrowhead). Magnification A: x400; D: x3,500
Copyright This image is from McNeish J, Proc Natl Acad Sci U S A 2000 Apr 11;97(8):4245-50. Copyright 2000 National Academy of Sciences, U.S.A. J:61679
Symbol Name
Abca1tm1Jdm ATP-binding cassette, sub-family A (ABC1), member 1; targeted mutation 1, John D McNeish
Allelic Composition Genetic Background
Abca1tm1Jdm/Abca1tm1Jdm DBA/1LacJ-Abca1tm1Jdm

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