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Phenotype Image Detail
Image
Caption (A) 5 week old Fgfr3tm2Wei/Fgfr3+ (right) with littermate +/+ control (left) the Fgfr3tm2Wei/Fgfr3+ is easily distinguished by dwarfism, as well as a rounded head. (B) Growth curve of the Fgfr3tm2Wei/Fgfr3+ right) and wild-type littermate. (C) Showing the distortion of the brain in the Fgfr3tm2Wei/Fgfr3+ mouse. (D) Skeletal defects in the Fgfr3tm2Wei/Fgfr3+ (upper), arrow points to the craniocervical junction and thoracic kyphosis; arrowhead indicates the facial shortening and overgrowth of incisor teeth. (E-H) Skull comparison of the Fgfr3tm2Wei/Fgfr3+ (G & H) and the wild-type (E&F) mice. Dorsal view E & G. Ventral view F & H. Abbreviations: foramen magnun (fm); frontal bone (fr); incisor teeth (inc); interparietal bone (ip); mandible (md); nasal bone (na); occipital bone (occ); parietal bone (pa); zygomatic arch (zg); mutant dwarf mouse (Mut); wild-type (Wt)
Copyright This image is from Wang Y, Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4455-60. Copyright 1999 National Academy of Sciences, U.S.A. J:54829
Associated
Alleles
Symbol Name
Fgfr3tm2Wei fibroblast growth factor receptor 3; targeted mutation 2, Weizmann Institute of Science
Associated
Genotypes
Allelic Composition Genetic Background
Fgfr3tm2Wei/Fgfr3+ involves: 129S1/Sv * 129X1/SvJ * MF1

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory