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Phenotype Image Detail
Image
Caption Spectrum of vascular tumors in livers of Vhltm1.1Jae/Vhl+ (VHL1/+) mice and histological comparison of Vhltm1.1Jae/Vhl+ vascular lesions with vascular lesions found in mice with hepatocyte specific ablation of Vhl (Vhltm1Jae/Vhltm1Jae Speer6-ps1Tg(Alb-cre)21Mgn/0; Albumin-cre mutant). Panel A. Formalin fixed livers of Vhltm1.1Jae/Vhl+ mice. (a) Gross photograph of a large cavernous hemangioma of the right liver lobe. (b) Gross photograph of a small vascular lesion in unsectioned liver. (c) Liver from Panel A(b) sectioned. The vascular lesion is indicated by the arrow. (d) Example of a medium-sized hemangioma of the right liver lobe. (e) Paraffin section of a cavernous hemangioma stained with H&E. The arrows point to cords of normal-appearing hepatocytes and stars depict vascular cavities. (f) CD31 immunostain of endothelial cells lining a large cavity. Panel B. Comparison of vascular lesions of Vhltm1.1Jae/Vhl+ mice with Vhltm1Jae/Vhltm1Jae Speer6-ps1Tg(Alb-cre)21Mgn/0 mice, at low-power and high-power magnification. Stars indicate endothelium-lined vascular spaces, straight arrows point to lipid-containing hepatocytes, and dashed arrows indicate small vascular spaces/vessels. Panel C. Analysis of hepatocellular lipid vacuoles by electron microscopy, and PCNA-staining of Vhltm1.1Jae/Vhl+ vascluar lesions. Shown on the left is a hepatocyte containing multiple lipid vaculoes (arrows), the appearance of which is consistent with neutral lipid (triglyceride). Shown on the right are PCNA-positive cells (arrows) in a typical vascular lesion; small vessels are marked with stars. Panel D. Foci of increased vascularization in Vhltm1.1Jae/Vhl+ and Vhltm1Jae/Vhltm1Jae Speer6-ps1Tg(Alb-cre)21Mgn/0 livers and CD31 immunostain of small vessels (arrows).
Copyright This image is from Haase VH, Proc Natl Acad Sci U S A 2001 Feb 13;98(4):1583-8. Copyright 2001 National Academy of Sciences, U.S.A. J:67505
Associated
Alleles
Symbol Name
Speer6-ps1Tg(Alb-cre)21Mgn spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson
Vhltm1.1Jae von Hippel-Lindau tumor suppressor; targeted mutation 1.1, Rudolf Jaenisch
Vhltm1Jae von Hippel-Lindau tumor suppressor; targeted mutation 1, Rudolf Jaenisch
Associated
Genotypes
Allelic Composition Genetic Background
Vhltm1.1Jae/Vhl+ involves: 129S4/SvJae * BALB/c
Vhltm1Jae/Vhltm1Jae
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory