Phenotype Image Detail

Image

Caption

Postnatal skeletal development of heterozygous Papss2^bm/Papss2⁺ (left) and homozygous Papss2^bm/Papss2^bm mutant (right) mice. Papss2^bm/Papss2^bm mice are characterized by a dome shaped skull, short thick tail and shortened but not widened limbs. The size difference becomes apparent over the first four weeks of life. There is a 50% reduction in the limb length and a 25% reduction in the axial skeletal size. Calcified bone and cartilage stained differentially with Alzarin red and Alcian blue respectively at P0, P10 and P30 (Inserts). Papss2^bm/Papss2⁺ (left) and Papss2^bm/Papss2^bm (right). Tibias of Papss2^bm/Papss2⁺ (left) and Papss2^bm/ Papss2^bm (right) showing the similar size in all skeletal elements at P0 and the slower increases in length at P10 and P30.

Associated
Alleles

Symbol	Name
Papss2^bm	3'-phosphoadenosine 5'-phosphosulfate synthase 2; brachymorphic

Associated
Genotypes

Allelic Composition	Genetic Background
Papss2^bm/Papss2^bm	LDJ/Le

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