About   Help   FAQ
Phenotype Image Detail
Image
Caption Harlequin mice exhibit paucity of fur resulting in near baldness in hemizygous males and homozygous females. Ataxia is noticeable by 5 months and progresses as the mice age. Initially the ataxia manifests itself as a side-to-side, unsteady gait with a lateral tremor visible at rest. Cell loss is greater in the caudal lobules of the cerebellum and is extensive by 9 to 11 months of age. Retinal degeneration is found beginning with ganglion and amacrine cell loss in the ganglion cell layer at 3 months of age, and progresses with cell loss in the inner and outer nuclear layers and reduction of rod and cone ERG responses at 4 months of age. By 10 months, the rod and cone ERG responses are gone, and at 11 months of age there isapparent cell loss in all layers of the retina.
Copyright Photo donated for Mouse Genome Informatics Database use. J:110244
Associated
Alleles
Symbol Name
Aifm1Hq apoptosis-inducing factor, mitochondrion-associated 1; harlequin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/07/2020
MGI 6.14
The Jackson Laboratory