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Molecular Image Detail
Image
Caption Generation of the Dclk2tm1Jgg and Dclk2tm1.2Jgg alleles. (A) Targeting strategy. Exon 2 was targeted by conditional strategy with HSV-TK as a negative and PKG-neo as a positive selection marker. Homologous recombination led to a conditional targeted allele Dclk2tm1Jgg (flox-neo). Complete removal of exon 2 was mediated by Cre recombinase, leading to a germ-line null allele, Dclk2tm1.2Jgg. This allele leads to an out-of-frame mutation and the appearance of a stop codon within the exon 3.
Copyright This image is from Kerjan G, Proc Natl Acad Sci U S A 2009 Apr 21;106(16):6766-71. Copyright 2009 National Academy of Sciences, U.S.A. J:148345
Associated
Alleles
Symbol Name
Dclk2tm1.2Jgg doublecortin-like kinase 2; targeted mutation 1.2, Joseph G Gleeson
Dclk2tm1Jgg doublecortin-like kinase 2; targeted mutation 1, Joseph G Gleeson

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory