Molecular Image Detail

Image

Caption

Generation of the Chat/Slc18a3^tm1Vpra (VAChT FloxNeo allele), Chat/Slc18a3^tm1.1Vpra (VAChT Del allele) and Chat/Slc18a3^tm1.2Vpra (VAChT Flox allele) alleles. a) Boxes represent the different exons of ChAT (Chat) or VAChT (Slc18a3). The position of the initiation codon (ATG) for VAChT and ChAT and the stop codon (Stop) of VAChT are indicated. Potential transcription initiation sites are indicated for VAChT (green arrowheads) and ChAT (orange arrowheads). Note that the VAChT gene is within the first intron of ChAT. b) Different VAChT alleles generated. P1, P2, P3 and P4 indicate the primers used for PCR genotyping and the fragment sizes generated. LoxP sequence, some restriction enzymatic sites and probe annealing are represented.

This image is from Martins-Silva C, PLoS One 2011;6(3):e17611, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171696

Associated
Alleles

Symbol	Name
Chat/Slc18a3^tm1.1Vpra	solute carrier family 18 (vesicular monoamine), member 3; targeted mutation 1.1, Vania Prado
Chat/Slc18a3^tm1.1Vpra	choline acetyltransferase; targeted mutation 1.1, Vania Prado
Chat/Slc18a3^tm1.2Vpra	solute carrier family 18 (vesicular monoamine), member 3; targeted mutation 1.2, Vania Prado
Chat/Slc18a3^tm1.2Vpra	choline acetyltransferase; targeted mutation 1.2, Vania Prado
Chat/Slc18a3^tm1Vpra	choline acetyltransferase; targeted mutation 1, Vania Prado
Chat/Slc18a3^tm1Vpra	solute carrier family 18 (vesicular monoamine), member 3; targeted mutation 1, Vania Prado

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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