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| Caption | Construction of the Snai3tm2.1Grid and Snai3tm2.2Grid alleles. Schematic representation of the wild-type Snai3 allele, the targeting vector, and the targeted allele in which an FRT-neo-FRT-loxP- cassette was inserted between exons 1 and 2, and the second loxP site was inserted 5' to exon 1. Removal of exon 1 and the neo cassette via cre-mediated recombination results in the Snai3tm2.2Grid allele. Removal of the neo cassette via flp-mediated recombination leaves exon 1 floxed and generates the Snai3tm2.2Grid allele. Exons are indicated by rectangles with coding sequences designated by gray shading, and noncoding sequences in black. A diphtheria toxin (DT) cassette was included for negative selection of randomly integrated clones. Hybridization probes used for Southern blot analyses are indicated. Abbreviations: B, BamHI; E, EcoRI; H,HindIII; N, NcoI; Nh, NheI; Sa, SalI; Sp, SpeI. | ||||||
| Copyright | This image is from Bradley CK, PLoS One 2013;8(6):e65344, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:198115 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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