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| Caption | Generation of the Arhgef26tm1.1Kbur allele. Schematic presentation of the murine ARHGEF26 (SGEF) protein (a) and gene (b). Domain structure of ARHGEF26 protein and genomic structure of the Arhgef26 gene are shown according to the database. Latin numbers indicate exon numbers. Roman numbers indicate the last and first codon position of each exon, respectively. (c) Enlarged area of exons 4/5. Numbers represent base pairs counted from 10 kB upstream of exon 4. The positions of cutting sites for selected DNA-endonucleases are indicated. The locations of the external probes P1 and P3 and the internal probe P4 are indicated as bars. (d) Schematic representation of the targeting vector. Filled triangles represent loxP sites; open triangles represent frt sites. Framed DNA-endonuclease recognition sites were introduced into the genomic DNA by the targeting construct. An endogenous ApaI site (at 9378) was destroyed by homologous recombination with the targeting construct and served to detect homologous integration of the construct. | ||||
| Copyright | This image is from Samson T, PLoS One 2013;8(1):e55202, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195919 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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