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| Caption | Generation of the Bub1btm2.1Jvd (BubR1GTTA) allele. Gene targeting strategy. Shown are: the genomic mouse Bub1b (BubR1) locus spanning exon 12 to 21 (top); the targeting vector (TV) with the GTTA insertion in exon 17 (asterisk), loxP sites (blue triangles); the Bub1b locus after targeted recombination; and the final Bub1btm2.1Jvd locus after protamine-Cre mediated recombination mice to excise the NEO cassette and produce the Bub1btm2.1Jvd allele. The Xmn1 (Xm) and Xho1 (Xh) restriction sites, the Southern blot probe, wild-type and BubR1NEO;GTTA Southern blot fragments and the 4 PCR primer sites (a-d) used for genotyping are indicated. | ||||
| Copyright | This image is from Wijshake T, PLoS Genet 2012;8(12):e1003138, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:194926 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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