About   Help   FAQ
Molecular Image Detail
Image
Caption Targeting of the ROSA26 locus. A, top to bottom: pBigT, plasmid containing a loxP-flanked cassette with a PGK-neo selection marker and tpA transcriptional stop sequence, followed by the EYFP or ECFP sequence; pROSA26PA, containing genomic ROSA26 sequences for homologous recombination, and a diphtheria toxin gene (PGK-DTA) for negative selection in ES cells; wild type ROSA26 locus, with the location of the probe indicated; the structure of the targeted allele (Gt(ROSA)26Sortm1(EYFP)Cos or Gt(ROSA)26Sortm2(ECFP)Cos ); the structure of the cre-recombined allele Gt(ROSA)26Sortm1.1(EYFP)Cos. Solid arrowheads indicate loxP sites.
Copyright This image is from Srinivas S, BMC Dev Biol 2001;1(1):4, an open-access article, licensee BioMed Central Ltd. J:80963
Associated
Alleles
Symbol Name
Gt(ROSA)26Sortm1.1(EYFP)Cos gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Frank Costantini
Gt(ROSA)26Sortm1(EYFP)Cos gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank Costantini
Gt(ROSA)26Sortm2(ECFP)Cos gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Frank Costantini

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/18/2022
MGI 6.17
The Jackson Laboratory