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Molecular Image Detail
Image
Caption Generation of the Pkd1tm1Fqi (Pkd1NeoV) and Pkd1tm1.1Fqi (Pkd1V) alleles by gene targeting. (A) Structure of various Pkd1 alleles. (i) Targeting vector. Neo, FRT-flanked (red triangle) PGK-neomycin selection cassette; TK, thymidine kinase gene; S, SpeI. Exons are depicted by solid boxes. The T3041V mutation is indicated. (ii) Wild-type (WT) allele, with exon number shown. (iii) Pkd1tm1Fqi (Pkd1NeoV) allele. The expected size of the SspI or SpeI restriction fragments for WT and Pkd1tm1Fqi (Pkd1NeoV) alleles by using the 5' probe (within exon 15 outside of the vector) is shown. The expected size of the 3' long-range PCR product is also shown. (iv) Pkd1tm1.1Fqi (Pkd1V) allele. A single FRT site of 47 bp is retained at the site of Neo insertion.
Copyright This image is from Yu S, Proc Natl Acad Sci U S A 2007 Nov 20;104(47):18688-93. Copyright 2007 National Academy of Sciences, U.S.A. J:127628
Associated
Alleles
Symbol Name
Pkd1tm1.1Fqi polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1.1, Feng Qian
Pkd1tm1Fqi polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1, Feng Qian

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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory