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| Caption | Targeting constructs used to create the Dkc1tm2Pjma and Dkc1tm3Pjma alleles. The diagram shows the Dkc1 gene with the exons represented as black rectangles. The arrows indicate the direction of transcription of the Dkc1 and adjacent Mpp1 genes. Targeting constructs consisted of exons 10-15 of the Dkc1 gene with a IRES-NEO element in the 3' UTR and point mutations in exons 11 (A353V) or 12 (G402E). The Dkc1tm2Pjma allele has the A353V mutation in exon 11 and the Dkc1tm3Pjma allele has the G402E mutation in exon 12. Probes and restriction enzymes used to analyze the targeted alleles in ES cells and mice are shown. B, BamHI; Bs, BspHI; H, HindIII; E, EcoRI. | ||||||
| Copyright | This image is from He J, Genesis 2009 Jun;47(6):366-73, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:149894 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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