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| Caption | Scheme for generation of the Cd68tm1Xfen allele. (A) Vector diagram with a neomycin phosphotransferase expression cassette (PGK-NEO) flanked by sequences with homology to targeted genomic sequence. A thymidine kinase expression cassette (PGK-TK) lies outside the homology region of vector. (B) Structure of targeted wild-type allele. A southern blot probe can hybridize to a genomic sequence outside of the homology region. P1 and P2 are primers that specifically amplify the sequence of CD68 targeted for replacement. (C) Recombined allele with exons 1 and 2 of CD68 gene replaced with PGK-NEO. Properly targeted recombined alleles do not contain the thymidine kinase expression cassette. P3 and P4 are primers that specifically amplify a region of PGK-NEO. | ||||
| Copyright | This image is from Ashley JW, PLoS One 2011;6(10):e25838, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:178120 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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