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| Caption | Strategy for generation of the conditional Aqp4tm1.1Geno allele. (A) FRT-neomycin-FRT-LoxP validated cassette was inserted downstream of exon 3, and a LoxP site was inserted upstream of exon 1. The Neo cassette was deleted by breeding chimeras with Flp recombinase-expressing mice. Mating of heterozygous Aqp4tm1.1Geno mice with Cre recombinase expressing mice (such as hGFAP-Cre) results in conditional knock-out of Aqp4. | ||||
| Copyright | This image is from Haj-Yasein NN, Proc Natl Acad Sci U S A 2011 Oct 25;108(43):17815-20. Copyright 2011 National Academy of Sciences, U.S.A. J:177412 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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