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Image
Caption (a) The targeted Fbn1 locus. A neomycin selection cassette (PGK-Neo, flanked by FRT sites) was placed in the intron between exons 10 and 11. In addition, loxP sites were introduced before exons 10 and 11 and after exon 12. The neomycin cassette was removed by breeding targeted mice to FLPe mice, generating the Fbn1tm3.1Lysa allele. Cre-mediated recombination of the loxP sites in the germline resulted in deletion of exons 10-12 and generated the Fbn1tm3.2Lysa allele, replicating the human Weill-Marchesani syndrome mutation.
Copyright This image is from Sengle G, PLoS Genet 2012 Jan;8(1):e1002425, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:181493
Associated
Alleles
Symbol Name
Fbn1tm3.1Lysa fibrillin 1; targeted mutation 3.1, Lynn Y Sakai
Fbn1tm3.2Lysa fibrillin 1; targeted mutation 3.2, Lynn Y Sakai

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory