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Caption (A) Strategy for targeting the Mapk14 (p38alpha) locus. The genomic structure, targeting vector, and targeted allele for Mapk14tm3.1(Mapk11)Nbr (p38betaKIalpha) are shown. The construct consisted of an in-frame-cloned Mapk11 (p38beta) cDNA fused to a SV40 polyA sequence followed by a loxP-flanked neomycin resistance cassette, a 3.3-kb 5' homology arm, and a 7.9-kb 3' homology arm. The A subunit of diphtheria toxin was used as a counter selection marker. Heterozygous mice containing the neomycin resistance cassette (p38beta KI alphaneo/+) mice were intercrossed with the CMV-Cre transgenic line to remove the neomycin resistance cassette.
Copyright This image is from del Barco Barrantes I, Proc Natl Acad Sci U S A 2011 Aug 2;108(31):12764-9. Copyright 2011 National Academy of Sciences, U.S.A. J:176023
Associated
Alleles
Symbol Name
Mapk11tm1Jsca mitogen-activated protein kinase 11; targeted mutation 1, J Simon C Arthur
Mapk14tm2Nbr mitogen-activated protein kinase 14; targeted mutation 14, Angel R Nebreda
Mapk14tm3.1(Mapk11)Nbr mitogen-activated protein kinase 14; targeted mutation 3.1, Angel R Nebreda
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory