Phenotype Image Detail

Image

Caption

Csnk1a1^tm1.1Ybn/Csnk1a1^tm1.1Ybn Tg(KRT14-cre/ERT)20Efu/0 (SKO) mice develop skin hyperpigmentation, but Csnk1a1^tm1.1Ybn/Csnk1a1^tm1.1Ybn Tg(KRT14-cre/ERT)20Efu/0 Trp53^tm1Brn/Trp53^tm1Brn (DKO) mice do not show skin hyperpigmentation. (C) Fontana-Masson staining of the paw skin. Melanin distribution in heterozygous control (Het) mice is mainly located in the dermis and less in the epidermis. In SKO mice, the epidermis becomes hyperplastic with increased melanin deposition. In DKO mice, the epidermis becomes dysplastic without melanin deposition. (Scale bars, 50 um.)

Copyright

This image is from Chang CH, Proc Natl Acad Sci U S A 2017 Sep 19;114(38):E8035-E8044. Copyright 2017 National Academy of Sciences, U.S.A. J:253611

Associated Alleles

Symbol	Name
Csnk1a1^tm1.1Ybn	casein kinase 1, alpha 1; targeted mutation 1.1, Yinon Ben-Neriah
Tg(KRT14-cre/ERT)20Efu	transgene insertion 20, Elaine Fuchs
Trp53^tm1Brn	transformation related protein 53; targeted mutation 1, Anton Berns

Associated Genotypes

Allelic Composition	Genetic Background
Csnk1a1^tm1.1Ybn/Csnk1a1^tm1.1Ybn Tg(KRT14-cre/ERT)20Efu/0	involves: 129S1/Sv * 129X1/SvJ * CD-1
Csnk1a1^tm1.1Ybn/Csnk1a1^tm1.1Ybn Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre/ERT)20Efu/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1