Phenotype Image Detail

Image

Caption

The endoplasmic reticulum (ER) is grossly distended, and collagen fibrils are reduced in Mia3^tm1Lex/Mia3^tm1Lex (Mia3^-/-) chondrocytes. (A-D) Comparative transmission EM (TEM) images of wild-type (WT) (A and C) and mutant (B and D) proliferative zone chondrocytes within the humerus. ER distention is clearly evident in the majority of null cells along with a concomitant reduction in extracellular collagen fibril assembly (asterisks). Nuc, nucleus.

Copyright

This image is from Wilson DG, J Cell Biol 2011 May 30;193(5):935-51, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:172737

Associated Alleles

Symbol	Name
Mia3^tm1Lex	MIA SH3 domain ER export factor 3; targeted mutation 1, Lexicon Pharmaceuticals
Mia3^tm1Lex	MIA SH3 domain ER export factor 3; targeted mutation 1, Lexicon Pharmaceuticals

Associated Genotypes

Allelic Composition	Genetic Background
Mia3^tm1Lex/Mia3^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6