Phenotype Image Detail

Image

Caption

Disorganized fiber orientation in Casz1^{Gt(CJ0565)Wtsi}/Casz1^{Gt(CJ0565)Wtsi} (Casz1^{betageo/betageo}) heart. To visualize thin filaments, wild-type (WT) and mutant E14.5 hearts were stained with phalloidin-488 (green) to detect F-Actin and co-stained with TOPRO3 to show cell nuclei. The left panels show the co-staining results of the left ventricles of the hearts. The right panels represent magnified areas delineated in the red squares in the left panels. Enlarged images showed complete disruption of the fiber orientation/cell alignment in the left ventricle (LV) of the mutant heart.

Copyright

This image is from Liu Z, J Biol Chem 2014 Oct 24;289(43):29801-16 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:242127

Associated Alleles

Symbol	Name
Casz1^Gt(CJ0565)Wtsi	castor zinc finger 1; gene trap CJ0565, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Casz1^Gt(CJ0565)Wtsi/Casz1^Gt(CJ0565)Wtsi	involves: 129P2/OlaHsd * C57BL/6