Phenotype Image Detail

Image

Caption

Pten^tm1Hwu/Pten^tm1Hwu Tg(Tyr-cre)1Lru/0 (HM) mice present hyperplasia of the enteric glial cells. (A) Transverse sections of wild-type (WT) and HM P15 colons were immunostained for GFAP, and double-immunostained for GFAP and PTEN. Merged immunofluorescence is shown for WT and HM. Note that GFAP-positive cells produce PTEN in WT colon, but do not contain any PTEN protein in the HM colon. Scale bar for immunohistochemistry: 50 um; scale bar for immunofluorescence: 25 um.

This image is from Puig I, J Clin Invest 2009 Dec;119(12):3586-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:155110

Associated
Alleles

Symbol	Name
Pten^tm1Hwu	phosphatase and tensin homolog; targeted mutation 1, Hong Wu
Tg(Tyr-cre)1Lru	transgene insertion 1, Lionel Larue

Associated
Genotypes

Allelic Composition	Genetic Background
Pten^tm1Hwu/Pten^tm1Hwu Tg(Tyr-cre)1Lru/0	B6.Cg-Pten^tm1Hwu Tg(Tyr-cre)1Lru

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23