Phenotype Image Detail

Image

Caption

Abnormal cell architecture and apical junctional complex (AJC) in the Pdcd6ip^tm1.2Adz/Pdcd6ip^tm1.2Adz (KO) choroid plexus (CP). (a) Transmission electron microscopy (TEM) revealed the misalignment of the epithelial cells, their irregular shape and size and the prominent blebbing of their microvilli (n = 2), Scale bar, 2 um. (b) SEM of the mutant CP apical surface showed extensive blebbing (yellow arrows) and large gaps between cells (light blue arrows) (n = 2), Scale bar, 2 um. (c) High-magnification TEM abnormally distended AJC in mutant CP (n = 3), Scale bar, 100 nm. (d) Immunostaining of whole-mount preparations for beta-catenin (green), and gamma-tubulin (red) demonstrated the abnormal cell shape and mislocalization of the basal bodies in the mutant CP (n = 2). Scale bar, 10 um.

Copyright

This image is from Campos Y, Nat Commun 2016 Jun 23;7():11876, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:238436

Associated Alleles

Symbol	Name
Pdcd6ip^tm1.2Adz	programmed cell death 6 interacting protein; targeted mutation 1.2, Alessandra d'Azzo

Associated Genotypes

Allelic Composition	Genetic Background
Pdcd6ip^tm1.2Adz/Pdcd6ip^tm1.2Adz	either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)